The NFL holds a lot of cultural significance in America in particular and the world in general. In America it is a cornerstone of life and serves as a unifying source of entertainment entity whenever games are played, such as Super Bowl Sunday serving as an unofficial holiday for most Americans with millions of parties and millions of Americans gathering together to watch the game.

The NFL impacts internationally by playing official league games in countries across the globe, bringing its excitement, hard hits, and competition to foreign citizens and exposing them to a bit of American culture.

Many cities and even states identities are shaped by the teams in their area such as Green Bay, Wisconsin, where the Packers are "A way of life, binding generations" 

Tailgating and Fantasy football give fans a chance to feel like they are a part of the league, and its influence plays a part in music, fashion, and especially advertising using its "unmatched cultural reach" to affect all of them.

The NFL props up social issues such as racial justice which began in 2020.  The NFL blends competition, entertainment, and current issues together to cement its influence on Americans and abroad.